| プロフィール | |
|---|---|
| 専門分野 | 分子生物学、免疫工学 |
| 学位 | 理学博士 |
| 最終学歴 | 東京工業大学大学院理工研究科博士後期課程 |
| 着任年月日 | 1994-04-01 |
| 研究活動 | |
| 著書・論文 |
Sachiko Hirose, Qingshun Lin, Mareki Ohtsuji , Hiroyuki Nishimura , J. Sjef Verbeek. Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis. 2019.
Qingshun Lin, Mareki Ohtsuji , Hirofumi Amano, Hiromichi Tsurui, Norihiro Tada, Ryota Sato, Hidehiro Fukuyama, Hiroyuki Nishimura, J. Sjef Verbeek, Sachiko Hirose. 「FcγRIIb on B cells and 1 myeloid cells modulates B cell activation and autoantibody」. The Journal of Immunology 2018 Dec 1.. 2018, 201(11):3199-3210..
Toshiaki Haga , Kenichi Mitsui, Junichi Toei, Mareki Ohtsuji , Yo Kodera, Kenichi Osada, Hiroyuki Nishimura. “Aberrant Light-Induced Depression Is Associated with Impaired Sensorimotor Gating in Mice”. World Journal of Neuroscience Vol.8 1-9, 2018, DOI: 10.4236/wjns.2018.81001. 2017.
佐藤 貴亮 , 西村 裕之 , 萩原 啓実, 吉田 薫, 竹内 真一. 「膵臓癌細胞のアポトーシス誘導に関する基礎研究」. 超音波29巻4号. 2017, 29巻4号, 16～19頁.
Kodera Y , Ohtsuji M, Shirai T, Hirose S, Nishimura H. “enetic factors involved in the pathogenesis of systemic lupus erythematosus”. Autoimmune Dis Ther Approaches 2: 1-9. 2015.
Masaomi Obata, Mareki Ohtsuji, Yukiyasu Iida , Toshikazu Shirai , Sachiko Hirose , Hiroyuki Nishimura. “Genome-Wide Genetic Study in Autoimmune Disease-Prone Mice”. Methods in Molec. Biol.. 2014, pp.111-143.
Masaomi Obata, Mareki Ohtsuji, Yukiyasu Iida, Toshikazu Shirai, Sachiko Hirose, Hiroyuki Nishimura. “Arthritis Reserch,Methods and Protocols”. Human press. 2014, 204.
Hideki Okazaki, Qingshun Lin, Keiko Nishikawa, Naomi Ohtsuji, Hiromichi Tsurui, Mareki Ohtsuji, Hirofumi Amano, Katsuko Sudo, Hiroyuki Nishimura, Toshikazu Shirai, Sachiko Hirose. “TNFα but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.”. Mod Rheumatol. in press. 2014.
Hideki Okazaki , Qingshun Lin, Keiko Nishikawa, Naomi Ohtsuji, Hiromichi Tsurui, Mareki Ohtsuji , Hirofumi Amano , Katsuko Sudo , Hiroyuki Nishimura , Toshikazu Shirai , Sachiko Hirose,. 「TNFα but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.」. Mod Rheumatol.. 2014.
林青順, 西川桂子, 鶴井博理, 広瀬幸子, 大辻希樹, 西村裕之. 「自己免疫疾患におけるSLAMファミリー受容体の関与」. 臨床免疫. 2013, 60(3), 258-262頁.
Obata M, Fujii T, Ohtsuji M , Kodera Y, Nishimura H. “Th cells induced with polyethylene glycol-conjugate of protein antigen”. Open J. Immunol., 3. 2013, pp.62-70.
Obata, M., Fujii, T. , Ohtsuji, M. , Kodera, Y. , Nishimura, H.. “Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen.”. Open J. Immunol., 3. 2013, pp.62-70.
金子俊之, 天野浩文, 西川桂子, 河野晋也, 大辻希樹, 西村裕之, 廣瀬幸子, 高崎芳成. 「SLEとRAの疾患特異性を決定する遺伝要因の解析」. Japanese Journal of Clinical Immunology 35(4). 2012, 328頁.
Keiko Okazaki, Yusuke Suzuki , Mareki Otsuji , Hitoshi Suzuki, Masao Kihara , Tadahiro Kajiyama, Azusa Hashimoto, Hiroyuki Nishimura , Rhubell Brown , Stacy Hall , Jan Novak , Shozo Izui , Sachiko Hirose , Yasuhiko Tomino. “Development of a model of early-onset IgA nephropathy”. J Am Soc Nephrol. 2012 Aug;23(8). 2012, pp.1364-1374.
K.Okazaki, Y.Suzuki, M.Otsuji, H.Suzuki, M.Kihara, T.Kajiyama, A.Hashimoto, H.Nishimura, R.Brouwn, S.Hall, J.Novak, S.Izui, S.Hirose, Y.Tomino. “Development of a model of early-onset lgA nephropathy”. J. Am. Soc. Nephrol. 2012. 2012, pp.1364-1374.
Tomoya Ohno, Noriaki Hashimoto, Kanako Yamazaki, Ken-ichi Mitsui , Hiroyuki Nishimura, Hiromi Hagiwara. “Iron Overload Inhibits Calcification and Differentiation of ATDC5 Cells”. Journal of Biochemistry・151(1). 2012, pp.109-114.
尾畑賢臣 , 藤原龍 , 西村裕之 , 小寺洋. 「ポエチレングリコール修飾抗原による免疫寛容の誘導」. 臨床免疫・アルギー科. 2011, 第56巻第4号, 429-433頁.
A.Sato-Hayashizaki, M.Ohtsuji, Q.Lin, R.Hou, N.Ohtsuji, K.Nishikawa, H.Tsurui, K.Sudo, M.Ono, S.Izui, T.Shirai, T.Takai, H.Nishimera, S.Hirose. “Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in new mouse model with Fcy receptor type llb-deficient C57BL/6 genetic background”. Arthritis Rheum. 2011. 2011, pp.2930-2938.
M.Obata, R.Fujiwara, H.Nishimura, Y.Kodera. 「ポリエチレングリコール修飾抗原による免疫寛容の誘導」. 臨床免疫・アレルギー科 第56巻4号. 2011. 2011, 第56巻4号, 1-5頁.
Fujii T, Hou R, Sato-Hayashizaki A, Obata M, Nishimura N, Ohtuji M, Ikeda K, Toei J, Mitsui K, Kodea Y, Shirai T, Hirose S, Nishimura H. “Susceptibility loci to for the defective foreign protein-induced tolerance in NZB mice: Implications of epistatic effects of Fcgr2b and Slam family genes”. Eur. J. Immunol. 2011. 2011, pp.2333-2340.
Fujii, T., Hou, R., Sato-Hayashizaki, A., Obata, M., Ohtsuji, M. , Ikeda, K., Mitsui, K., Kodera, Y. , Shirai, T., Hirose, S. , Nishimura H.. “Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes.”. Eur. J. Immunol., vol 41. 2011, vol 41, pp.2333-2340.
T.Ohno, N.Hashimoto, K.Mitsui, H.Nishimura, H.Hagiwara. “Iron overload inhibits calcification and differentiation of ATDC5 cells”. J.Biochem. 2012. 2011, pp.109-114.
Nobutaka KUWAHARA, Yasuhiro IIDA, Hiroyuki NISHIMURA and Yukiyasu IIDA. “Development of a simulation system for SLE disease model mice crossing experiment”. Reseach Bulletin No.24. 2010, No.24, pp.159-163.
Obata, M., Fujiwara, R., Fujii, T., Kodera, Y. , Ohtsuji, M. , Hirose, S., Nishimura, H.. “Antigen-specific immune tolerance induced by protein antigens conjugated with polyethylene glycol.”. 桐蔭論叢 第22号. 2010, 22号.
Masaomi OBATA, Ryu FUJIWARA, Takuma FUJII, Yo KODERA, Mareki OHTSUJI, Sachiko HIROSE and Hiroyuki NISHIMURA. “Antigen-Specific Immune Tolerance Induced by Protein Antigens Conjugated with Polyethylene Glycol”. 桐蔭論叢第22号. 2010, 22号, pp.5-12.
Q.Lin, R.Hou, A.Sato, M.Ohtsuji, N.Ohtsuji, K.Nishikawa, H.Tsurui, H.Amano, E.Amano, K.Sudo, H.Nishimura, T.Shirai and S.Hirose. “Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus”. J.Autoimmun 34. 2010, 34, pp.356-363.
M.Ohta, T.Ohshima, H.Nishimura, N.Maeda and Y.Asada. “Mapping of a gene influencing initial dental caries susceptibility to chromosome 11”. Pediatric Dent.J.20. 2010, pp.84-90.
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| 研究発表等 |
Mareki Ohtsuji, Qingshun Lin, Hidehiro Fukuyama, Hirofumi Amano, Hiroyuki Nishimura, J. Sjef Verbeek, Sachiko Hirose. "「 Contribution of monocyte subsets in autoimmune diseases.」". The 48th Annual Meeting of Japanese Society for Immunology , Hamamatsu, Japan. Hamamatsu, Japan, 2019.
Hiroyuki Nishimura, Noriko Iida, Mareki Ohtsuji, Yo Kodera, Toshiyuki Takai, Katsuko Sudo, J. Sjef Verbeek, Sachiko Hirose. "「Epistatic interaction between Fcgr2b and slam family genes in susceptibility to the defective peripheral immune tolerance and autoimmunity.」". The 48th Annual Meeting of Japanese Society for Immunology , Hamamatsu, Japan. Hamamatsu, Japan, 2019.
Kazuko Takahashi, Mareki Ohtsuji, Qingshun Lin, Hideki Okazaki, Hirofumi Amano, Hideo Yagita, Hiroyuki Nishimura, Sachiko Hirose. "「Anti-CD11b antibody treatment suppresses the disease conditions in rheumatoid arthritis (RA)-prone, FcγRIIB-deficient mice」". IMMUNOLOGY 2019 , SAN DIEGO CONBENTION CENTER. 2019.
OHTSUJI Mareki, AMANO Hirofumi, OKAZAKI Hieki, NISHIMURA Hiroyuki, HIROSE Sachiko. "「Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice.」". The 63st Annual General Assembly and Scientific Meeting of the Japan College Rheumatology , Kyoto,Japan. 2019.
Hiroyuki Nishimura, Masaomi Obata, Mareki Ohtsuji, Yo Kodera, Toshiyuki Takai, Katsuko Sudo, J.Sjef Verbeek, Sachiko Hirose. "「Epistatic interaction between fcgr2b and Slam family genes in susceptibility to defective foreign protein-induced tolerance」". The 47th Annual Meeting of Japanese Society for Immunology. 2018.
Mareki Ohtsuji, Qingshun Lin, Hirofumi Amano, Hideo Yagita , Kazuko Takahashi, Hideki Okazaki, Hiroyuki Nishimura, Hirose Sachiko. "「Treatment with anti-CD11b antibody ameliorates arthritis in novel arthritis-prone mouse model」". The 47th Annual Meeting of Japanese Society for Immunology Fukuoka, Japan. 2018.
Mareki Ohtsuji, Qingshun Lin, Hirofumi Amano , Hideo Yagita , Kazuko Takahashi , Hideki Okazaki , Hiroyuki Nishimura , Hirose Sachiko. "“Inhibitory effect of the blocking of monocyte recruitment from the blood on spontaneously occurring”". The 46th Annual Meeting of The Japanese Society for Immunology Sendai International Center（2017年12月12日～14日）. Sendai International Center, 2017.
Hiroyuki Nishimura , Masaomi Obata, Mareki Ohtsuji , Yo Kodera , Toshiyuki Takai, Katsuko Sudo, Sachiko Hirose. "“Epistatic interaction between fcgr2b and Slam family genes in susceptibility to defective foreign proteininduced”". The 46th Annual Meeting of The Japanese Society for Immunology Sendai International Center（2017年12月12日～14日）. Sendai International Center, 2017.
Sachiko Hirose, Qingshun Lin, Mareki Ohtsuji, Hirofumi Amano, Hidehiro Fukuyama, Hiroyuki Nishimura, Sjef Verbeek. "“Independent effect of inhibitory IgG Fc receptor IIB on B cells and monocytes on Yaa-induced murine”". The 46th Annual Meeting of The Japanese Society for Immunology Sendai International Center（2017年12月12日～14日）. Sendai International Center, 2017.
S. Hirose, L. Qingshun, M. Ohtsuji, H. Nishimura , H. Amano, S. J. Verbeek. "“ROLE OF INHIBITORY IGG FC RECEPTOR IIB ON B CELLS AND MONOCYTES IN YAA-RELATED MURINE”". EULAR 2017(欧州リウマチ学会議 ) Madrid(Reino de España)（2017年6月14日～17日）. 2017.
大辻 希樹, 林 青順, 天野 浩文, 岡崎 英規, 西村 裕之, 広瀬 幸子. "「抗CD11b投与によるFcgRⅡB欠損マウスに自然発症する関節炎の抑制効果」". 第61回 日本リウマチ学会総会・学術集会 福岡国際会議場. 福岡国際会議場, 2017.
広瀬 幸子, 林 青順, 大辻 希樹 , 天野 浩文 , 西村 裕之. "「ループス腎炎の発症におけるIgG Fc receptor ⅡB欠損の役割に関する細胞レベルでの解析」". 第61回 日本リウマチ学会総会・学術集会 福岡国際会議場. 福岡国際会議場, 2017.
LIN Qingshun , TSURUI Hiromichi , AMANO Hirohumi, NISHIKAWA Keiko, OHTSUJI Mareki , NISHIMURA Hiroyuki , J.Sjef.Verbeek , HIROSE Sachiko. "“Inhibitory IgG Fc receptor IIB on B cells and monocytes independenly controls Yaa-induced murine lupus”". 日本免疫学会 沖縄（2016年12月5日～7日）. 沖縄, 2016.
NISHIMURA Hiroyuki, FUJII Takuma , OBATA Masaomi, OHTSUJI Mareki , KODERA Yo , TAKAI Toshiyuki , SUDO Katsuko , HIROSE Sachiko. "“Epistatic interaciton between fcgr2b and Slam family genes in susceptibility to defective foreign proteininduced tolerance”". 日本免疫学会 沖縄（2016年12月5日～7日）. 沖縄, 2016.
OHTSUJI Mareki LIN Qingshun, OKAZAKI Hideki , IKEDA Shuri , SASAKI Hinako , AMANO Hirofumi, YAGITA Hideo , NISHIMURA Hiroyuki , HIROSE Sachiko. "“Blocking of CD11b+ cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcγRIIB-deficient mouse model”". 日本免疫学会 沖縄（2016年12月5日～7日）. 2016.
Lin Qingshun , Tsurui Hiromichi , Keiko Nishikawa, Amano Hirofumi, Ohtsuji Mareki, Nishimura Hiroyuki , Shirai Toshikazu , J.Sjef.Verbeek , Hirose Sachiko. "“Cell Type-specific role of inhibitory IgG Fc receptor ⅡB in Yaa-induced murine lupus”". The 44th Annual Meeting of japanese Society for Immunology Sapporo Conbebtion Center. 2015.
Keiko Nishikawa , Lin Qingshun , Tsurui Hiromichi , Amano Hirofumi, Okazaki Hideki , Ohtsuji Mareki, Shirai Toshikazu , Hirose Sachiko , Nishimura Hiroyuki. "“Role of inhibitory FcγRⅡb and autoimmune-prone SLAM haplotype in autoimmune disease”". The 44th Annual Meeting of japanese Society for Immunology Sapporo Conbebtion Center. 2015.
林青順 , 西川桂子, 大辻希樹, 天野浩文 , 西村裕之 , 白井俊一 , 広瀬幸子. "「細胞特異的FcγRⅡB発現欠損マウスの樹立によるYaa誘導ループス腎炎発症機序の解明」". 第59回 日本リウマチ学会・総会名古屋国際会議場. 名古屋国際会議場, 2015.
大辻希樹 , 林青順 , 西川桂子 , 岡崎英規 , 天野浩文 , 西村裕之 , 西本憲弘, 白井俊一, 広瀬幸子. "“Preventive and therapeutic effects of anti-IL-6 receptor antibody on spontaneously occurring rheumatoid arthritis in an FcRIIB-deficient mouse model ”". 第59回 日本リウマチ学会・総会名古屋国際会議場. 名古屋国際会議場, 2015.
Mareki Ohtsuji , Hideki Okazaki , Qingshun Lin , Keiko Nishikawa , Hiroyuki Nishimura , Hirofumi Amano , Norihiro Nishimoto , Toshikazu Shirai , Sachiko Hirose. "“TNFα and IL-6 but not IL-17 are critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcRIIB-deficient mouse model.”". 第43回日本免疫学会総会・学術集会 京都. 京都, 2014.
Qingshun Lin , Turui Hirimichi , Nishikawa Keiko , Amano Hirofumi , Ohtsuji Mareki , Nishimura Hiroyuki, Shirai Toshikazu , Verbeek.J.Sjef , Hirose Sachiko. "“B cell specific FcγRIIb deficiency is enough for autoantibody production, but not for the progression of Yaa-related severe lupus nephritis”". 第43回日本免疫学会総会・学術集会 京都. 京都, 2014.
Hirosa Fusako, Obata Masaomi , Kodera Yo , Ohtsuji Mareki , Shirai Toshikazu, Hirose Sachiko , Nishimura Hiroyuki. "“Gene expression profile in spleen cells of (NZB x NZW)F1 mice with overt SLE activity”". 第43回日本免疫学会総会・学術集会 京都. 京都, 2014.
Qingshun Lin, Keiko Nishikawa, Mareki Ohtsuji, Hiroyuki Nishimura, Hirofumi Amano, Sachiko Hirose. "“B cell specific deficiency of FcγRIIB is required for autoantibody production,but not enough for early onset lupus nephritis in B6.Yaa mice”". 第58回日本リウマチ学会総会・学術集会（東京）. 東京, 2014.
Mareki Ohtsuji, Qingshun Lin, Keiko Nishikawa, Hideki Okazaki, Hiroyuki Nishimura, Norihiro Nishimoto, Sachiko Hirose. "“IL-6 signal blockade ameliorates spontaneously occurring rheumatoid arthritis in an FcγRIIB-deficient mouse model through loss of RANKL/OPG balance”". 第58回日本リウマチ学会総会・学術集会（東京）. 東京, 2014.
Masaomi Obata, Mareki Ohtsuji , Toshikazu Shirai, Sachiko Hirose, Hiroyuki Nishimura. "“Peripheral tolerance of antigen-specific Th cell induced with polyethylene glycol-conjugate of protein antigen.”". 第42回日本免疫学会学術集会. 2013.
OBATA Masaomi, OHTSUJI Mareki, HIRAI Toshikazu, HIROSE Sachiko, NISHIMURA Hiroyuki. "“Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen.”". 第42回 日本免疫学会総会・学術集会記録（幕張）. 幕張, 2013.
LIN Qingshun, NISHIKAWA Keiko, TSURUI Hiromichi, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, AMANO Hirofumi, SHIRAI Toshikazu, HIROSE Sachiko. "“B cell specific deficiency of FcgRIIB results in high levels of autoantibodies without severe lupus nephritis in C57BL/6.Yaa mice.”". 第42回 日本免疫学会総会・学術集会記録（幕張）. 幕張メッセ, 2013.
OKAZAKI Hideki, LIN Qingshun, NISHIKAWA Keiko, TSURUI Hiromichi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, HIROSE Sachiko. "“Blockade of TNFa, but not IL-17, ameliorates spontaneously occurring autoimmune arthritis in FcgRIIB-deficient mice.”". 第42回 日本免疫学会総会・学術集会記録（幕張）. 幕張メッセ, 2013.
Obata, M., Fujii, T., Ohtsuji, M., Kodera, Y. and Nishimura, H.. "“Peripheral tolerance of antigen-specific Th cell induced with polyethylene glycol-conjugate of protein antigen”". 8th TOIN International Symposium on Biomedical Engineering 2013, Toin University of Yokohama. Toin University of Yokohama, 2013.
OBATA Masaomi, OHTSUJI Mareki, SHIRAI Toshikazu, HIROSE Sachiko, NISHIMURA Hiroyuki. "“Mechanism of Th cell tolerance induced with tolerogenic polyethylene glycol(PEG)-conjugate of protein antigen”". 第41回 日本免疫学会総会・学術集会（神戸）. 神戸, 2012.
Obata, M., Kodera, Y., Ohtsuji, M., Shirai, T., Hirose, S. and Nishimura, H.. "“Mechanism of Th-cell tolerance induced with the tolerogenic protein antigen conjugated with polyethylene glycol”". 7th TOIN International Symposium on Biomedical Engineering 2012, Toin University of Yokohama. Toin University of Yokohama, 2012.
広瀬幸子, 佐藤 綾, 林 青順, 天野浩文, 大辻希樹, 西村裕之. "「篤な関節リウマチを自然発症するFcγレセプターIIB欠損マウスの樹立」". 56回日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集（東京）. 東京, 2012.
A.Sato, M.Ohtsuji, Q.Lin, N.Ohtsuji, K.Nishikawa, H.Tsurui, M.Ono, T,Shirai, T.Takai, H.Nishimura, S.Hirose. "“Presumptive role of 129 strain-derived Sle16 locus for rheumatoid arthritis in a new mouse model with FcyRⅡB-deficient C57BL/6 genetic background”". 40th Japanese Society for Immunology, 2011, Makuhari（2011年11月27日 ～11月29日）. Makuhari, 2011.
R.Fujiwara, M.Obata,T.Fujii, M.Ohtsuji, Y.Kodera, S.Hirose and H.Nishimura. "“Mechanism of Th-cell tolerance inudced with the torelogenic protein antigen conjugated with polyetylene glycol”". 40th Japanese Society for Immunology, 2011, Makuhari（2011年11月27日 ～11月29日）. Makuhari, 2011.
Q.Lin, M.Ohtsuji, A.Sato, N.Ohtsuji, K.Nishikawa, H.Tsurui, K.Sudo, H.Nishimura, M.Ono, T.Shirai, S.Hirose. "“The role of SLAM signal in SLE”". 40th Japanese Society for Immunology, 2011, Makuhari（2011年11月27日 ～11月29日）. Makuhari messe, 2011.
藤原 龍, 尾畑賢臣, 藤井琢磨, 大辻希樹, 小寺 洋, 広瀬幸子, 西村裕之. "「ポリエチレングリコール修飾抗原により誘導されるTh細胞免疫寛容の機序」". 第40回日本免疫学会学術集会・学術集会（千葉幕張）. 千葉幕張, 2011.
Hiroki IKEDA, Mareki OHTSUJI, Masaomi OBATA, Yo KODERA, Hiroyuki NISHIMURA. "“Interleukin 21 Chemically Conjugated with Polyethylene Glycol: Potential Application in Ttumor Immunotherapy”". 6th TOIN International Symposium on Biomedical Engineering 2011, Toin University of Yokohama. Toin University of Yokohama, 2011.
Ryu FUJIWARA, Masaomi OBATA, Takumka FUJII, Yo KODERA, Sachiko HIROSE, Hiroyuki NISHIMURA. "“Mechanism of Th-cell Tolerance Induced with The Tolerogenic Protein Antigen Conjugated with Polyethylene Glycol”". 6th TOIN International Symposium on Biomedical Engineering 2011, Toin University of Yokohama. Toin University of Yokohama, 2011.
Hiroki IKEDA, Mareki OHTSUJI, Masaomi OBATA, Yo KODERA, Hiroyuki NISHIMURA. "(Poster)“Interleukin 21 Chemically Conjugated with Polyethylene Glycol: Potential Application in Ttumor Immunotherapy”". 6th TOIN International Symposium on Biomedical Engineering 2011, Toin University of Yokohama. Toin University of Yokohama, 2011.
Ryu FUJIWARA, Masaomi OBATA, Takumka FUJII, Yo KODERA, Sachiko HIROSE, Hiroyuki NISHIMURA. "“Mechanism of Th-cell Tolerance Induced with The Tolerogenic Protein Antigen Conjugated with Polyethylene Glycol”". 6th TOIN International Symposium on Biomedical Engineering 2011, Toin University of Yokohama. Toin University of Yokohama, 2011.
相澤ゆかり、大辻稀樹、藤原龍、福森健、守永梓紗、西村裕之. "「自己免疫疾患感受性におけるSLAM遺伝子群の関与の可能性」". 第33回日本分子生物学会年会、 第83回日本生化学会大会合同学会、 神戸（2010年12月7日 ～10日）. 神戸, 2010.
Nobutaka KUWAHARA, Yasuhiro IIDA, Hiroyuki NISHIMURA and Yukiyasu IIDA. "“Improvement of the simulation program for the analysis of the mouse model of the autoimmune disease”". Toin International Symposium on Biomedical Engineering 2010, Yokohama. Yokohama, 2010.
M. Obata, R Fujiwara, Y.Kodera, M. Ohtsuji, S.Hirose and H. Nishimura. "“Genetic studies on immune tolerance”". Toin International Symposium on Biomedical Engineering 2010, Yokohama. Yokohama, 2010.
R.Fujiwara, K.Fukumori, M.Obata,T.Fujii, M.Ohtsuji, Y.Kodera, S.Hirose and H.Nishimura. "“Differential responses of ovalbumin-specific Tｈ-cells towards chemically-modified immunogenic and tolerogenic ovalbumins”". Toin International Symposium on Biomedical Engineering 2010, Yokohama. Yokohama, 2010.
Y.Aizawa, K.Fukunaga, M.Ohtsuji, T.Shirai, Y.Kodera, S.Hirose and H.Nishimura. "“The role of SAP (SLAM-associated protein) gene in the pathogenesis of Systemic lupus erythematosus.”". Toin International Symposium on Biomedical Engineering 2010, Yokohama. Yokohama, 2010.
K.Fukunaga , Y.Aizawa , M .Ohtsuji, T.Shirai, Y.Kodera, S.Hirose and H.Nishimura. "“Role of autoimmunity in the development of ankylosing enthesitis in (BXSB x NZB)F1 male mice.”". Toin International Symposium on Biomedical Engineering 2010, Yokohama. Yokohama, 2010.
M. Obata, R Fujiwara, T. Fujii, Y.Kodera, M. Ohtsuji, T. Shirai , S.Hirose, H. Nishimura. "“Mechanism of Thcell tolerance induced with thetolerogenic protein antigen conjugated with polyethylene glycol”". 14th International Congress of Immunology, Kobe（2010年8月22日 ～27日）. 2010.
S. Hirose, Q. Lin, A. Sato, R.Hou, M. Ohtsuji, H. Tsurui, H.Nishimura, T. Shirai. "“Genetics of autoimmunity”". 14th International Congress of Immunology, Kobe（2010年8月22日 ～27日）. 2010.
尾畑賢臣, 藤井琢磨, 小寺洋, 大辻希樹, 白井俊一, 広瀬幸子, 西村裕之. "「ポリエチレングリコール修飾抗原タンパク質によって誘導される抗原特異的免疫寛容」". 第39回日本免疫学会学術集会 大阪. 大阪, 2010.
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| 所属学会 |
日本免疫学会、日本分子生物学会、日本癌学会、日本生化学会、日本臨床免疫学会、日本リウマチ学会
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| 学会等および社会における主な活動 | |
| 芸術、体育実技、課外活動における業績 | |