| プロフィール | |
|---|---|
| 専門分野 | 生物化学、タンパク質工学 |
| 学位 | 理学博士 |
| 最終学歴 | 東京工業大学理学部 |
| 着任年月日 | 1988-04-01 |
| 研究概要 | ポリエチレングリコールを用いたタンパク質の化学修飾。 |
| 教育概要 | 【作成した教科書、教材、参考書】
市販教科書からの引用により作成したプリント（2005年～現在）を参考のため配布している。 |
| 研究活動 | |
| 著書・論文 |
Toshiaki Haga , Kenichi Mitsui, Junichi Toei, Mareki Ohtsuji , Yo Kodera, Kenichi Osada, Hiroyuki Nishimura. “Aberrant Light-Induced Depression Is Associated with Impaired Sensorimotor Gating in Mice”. World Journal of Neuroscience Vol.8 1-9, 2018, DOI: 10.4236/wjns.2018.81001. 2017.
Kodera Y , Ohtsuji M, Shirai T, Hirose S, Nishimura H. “enetic factors involved in the pathogenesis of systemic lupus erythematosus”. Autoimmune Dis Ther Approaches 2: 1-9. 2015.
Kodera, Y., Ohtsuji, M., Shirai, T., Hirose, S., and Nishimura, H.. “Genetic factors involved in the pathogenesis of systemic lupus erythematosus”. Mini-reviews in Medical Chemistry, in press.. 2015, -.
Obata, M., Fujii, T., Ohtsuji, M., Kodera, Y. and Nishimura, H.. “Th cells induced with polyethylene glycol-conjugate of protein antigen”. Open J. Immunol., 3. 2013, pp.62-70.
Obata, M., Fujii, T., Ohtsuji, M., Kodera, Y. and Nishimura, H.. “Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen”. Open J. Immunol., 3. 2013, pp.62-70.
尾畑賢臣 , 藤原龍 , 西村裕之 , 小寺洋. 「ポエチレングリコール修飾抗原による免疫寛容の誘導」. 臨床免疫・アルギー科. 2011, 第56巻第4号, 429-433頁.
Fujii T, Hou R, Sato-Hayashizaki A, Obata M, Nishimura N, Ohtuji M, Ikeda K, Toei J, Mitsui K, Kodea Y, Shirai T,. “Susceptibility loci to for the defective foreign protein-induced tolerance in NZB mice: Implications of epistatic effects of Fcgr2b and Slam family genes”. Eur. J. Immunol. 2011. 2011, pp.2333-2340.
尾畑賢臣、藤原龍、西村裕之、小寺洋. ｢ポエチレングリコール修飾抗原による免疫寛容の誘導｣. 臨床免疫・アルギー科,. 2011, 56(4), 429-433頁.
Fujii, T., Hou, R., Sato-Hayashizaki, A., Obata, M., Ohtsuji, M. , Ikeda, K., Mitsui, K., Kodera, Y. , Shirai, T.,. “Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes.”. Eur. J. Immunol.,. 2011, vol 41, pp.2333-2340.
Masaomi OBATA, Ryu FUJIWARA, Takuma FUJII, Yo KODERA, Mareki OHTSUJI, Sachiko HIROSE and Hiroyuki NISHIMURA. “Antigen-Specific Immune Tolerance Induced by Protein Antigens Conjugated with Polyethylene Glycol”. 桐蔭論叢. 2010, 第22号, pp.5-12.
Obata, M., Fujiwara, R., Fujii, T., Kodera, Y. , Ohtsuji, M. , Hirose, S., Nishimura, H.. “Antigen-specific immune tolerance induced by protein antigens conjugated with polyethylene glycol.”. 桐蔭論叢. 2010, 第22号.
|
| 研究発表等 |
Hiroyuki Nishimura , Noriko Iida, Mareki Ohtsuji , Yo Kodera , Toshiyuki Takai , Katsuko Sudo , J. Sjef Verbeek, Sachiko Hirose. "「Epistatic interaction between Fcgr2b and slam family genes in susceptibility to the defective peripheral immune tolerance and autoimmunity.」". The 48th Annual Meeting of Japanese Society for Immunology , Hamamatsu, Japan. Hamamatsu, Japan, 2019.
Hiroyuki Nishimura, Masaomi Obata, Mareki Ohtsuji, Yo Kodera, Toshiyuki Takai, Katsuko Sudo, J.Sjef Verbeek, Sachiko Hirose. "「Epistatic interaction between fcgr2b and Slam family genes in susceptibility to defective foreign protein-induced tolerance」". The 47th Annual Meeting of Japanese Society for Immunology. 2018.
Hiroyuki Nishimura , Masaomi Obata, Mareki Ohtsuji , Yo Kodera , Toshiyuki Takai, Katsuko Sudo, Sachiko Hirose. "“Epistatic interaction between fcgr2b and Slam family genes in susceptibility to defective foreign proteininduced”". The 46th Annual Meeting of The Japanese Society for Immunology. Sendai International Center, 2017.
NISHIMURA Hiroyuki, FUJII Takuma , OBATA Masaomi, OHTSUJI Mareki , KODERA Yo , TAKAI Toshiyuki , SUDO Katsuko , HIROSE Sachiko. "“Epistatic interaciton between fcgr2b and Slam family genes in susceptibility to defective foreign proteininduced tolerance” ". 日本免疫学会. 沖縄, 2016.
Hirono Fusako, Obata Masaomi , Kodera Yo, Ohtsuji Mareki, Shirai Toshikazu, Hirose Sachiko, Nishimura Hiroyuki. "“Genetic control of the abnomal activation and sequestrarion of splenic CD4+ Tcells in autoimmune diseaseprone (NZB x NZW)F1 hybrid mice” ". The 44th Annual Meeting of japanese Society for Immunology. Sapporo Conbebtion Center, 2015.
Hirosa Fusako, Obata Masaomi , Kodera Yo , Ohtsuji Mareki , Shirai Toshikazu, Hirose Sachiko , Nishimura Hiroyuki. "“Gene expression profile in spleen cells of (NZB x NZW)F1 mice with overt SLE activity” ". 第43回日本免疫学会総会・学術集会. 京都, 2014.
Obata, M., Fujii, T., Ohtsuji, M., Kodera, Y. and Nishimura, H.. "“Peripheral tolerance of antigen-specific Th cell induced with polyethylene glycol-conjugate of protein antigen” ". 8th TOIN International Symposium on Biomedical Engineering 2013. Toin University of Yokohama, 2013.
Obata, M., Kodera, Y., Ohtsuji, M., Shirai, T., Hirose, S. and Nishimura, H.. "“Mechanism of Th-cell tolerance induced with the tolerogenic protein antigen conjugated with polyethylene glycol” ". 7th TOIN International Symposium on Biomedical Engineering 2012. Toin University of Yokohama, 2012.
藤原 龍, 尾畑賢臣, 藤井琢磨, 大辻希樹, 小寺 洋, 広瀬幸子, 西村裕之. "「ポリエチレングリコール修飾抗原により誘導されるTh細胞免疫寛容の機序」". 第40回日本免疫学会学術集会・学術集会. 千葉幕張, 2011.
Hiroki IKEDA, Mareki OHTSUJI, Masaomi OBATA, Yo KODERA, Hiroyuki NISHIMURA. "“Interleukin 21 Chemically Conjugated with Polyethylene Glycol: Potential Application in Ttumor Immunotherapy” ". 6th TOIN International Symposium on Biomedical Engineering 2011. Toin University of Yokohama, 2011.
Ryu FUJIWARA, Masaomi OBATA, Takumka FUJII, Yo KODERA, Sachiko HIROSE, Hiroyuki NISHIMURA. "“Mechanism of Th-cell Tolerance Induced with The Tolerogenic Protein Antigen Conjugated with Polyethylene Glycol” ". 6th TOIN International Symposium on Biomedical Engineering 2011. Toin University of Yokohama, 2011.
Masaomi OBATA, Ryu FUJIWARA, Takuma FUJII, Yo KODERA, Mareki OHTSUJI, Sachiko HIROSE, Hiroyuki NISHIMURA. "“Genetic Studies on Immune Tolerance” ". TOIN International Symposium on Biomedical Engineering 2010. Toin University of Yokohama, 2010.
Kanami FUKUNAGA, Yukari AIZAWA, Yukiho OGAWA, Azusa MORINAGA, Mareki OHTSUJI, Toshikazu SHIRAI, Yo KODERA, Sachiko HIROSE, Hiroyuki NISHIMURA. "“Role of autoimmunity in the development of ankylosing enthesitis in (BXSB x NZB)F1 male mice”". TOIN International Symposium on Biomedical Engineering 2010. Toin University of Yokohama, 2010.
Ryu FUJIWARA, Ken FUKUMORI, Masaomi OBATA, Takuma FUJII, Mareki OHTSUJI, Yo KODERA, Sachiko HIROSE, Hiroyuki NISHIMURA. "“Differential responses of ovalbumin-specific Th cells towards chemically-modified immunogenic and tolerogenic ovalbumins”". TOIN International Symposium on Biomedical Engineering 2010. Toin University of Yokohama, 2010.
Yukari AIZAWA, Kanami FUKUNAGA, Mareki OHTSUJI, Toshikazu SHIRAI, Yo KODERA, Sachiko HIROSE, Hiroyuki NOSHIMURA. "“The role of SAP (SLAM-associated protein) gene in the pathogenesis of Systemic Lupus Erythematosus”". TOIN International Symposium on Biomedical Engineering 2010. Toin University of Yokohama, 2010.
M. Obata, R Fujiwara, T. Fujii, Y.Kodera, M. Ohtsuji, T. Shirai , S.Hirose, H. Nishimura. "“Mechanism of Thcell tolerance induced with thetolerogenic protein antigen conjugated with polyethylene glycol” ". 14th International Congress of Immunology. Kobe, 2010.
尾畑賢臣, 藤井琢磨, 小寺洋, 大辻希樹, 白井俊一, 広瀬幸子, 西村裕之. "「ポリエチレングリコール修飾抗原タンパク質によって誘導される抗原特異的免疫寛容」 ". 第39回日本免疫学会学術集会 大阪. 大阪, 2010.
|
| 所属学会 |
日本生化学会、日本免疫学会
|
| 学会等および社会における主な活動 | |
| 学会等および社会における活動 |
東進予備校、神奈川新聞社主催 パシフィコ横浜にて遺伝子を扱う実習体験の提供 (2011年9月25日)
かながわ発・中高生のための大学セミナー実行委員会 横浜新都市ホールにて遺伝子多型に関する体験の提供 (2011年7月16日)
|
| 芸術、体育実技、課外活動における業績 | |